The Nicholas Lab

Why We Slay

The Nicholas lab studies the intersection of the nutrient environment, the immune system, and metabolic disease using a combination of molecular and cellular biology, transgenic mouse models, cytokine profiling, and flow cytometry. We are focused on disease models of type 2 diabetes and polycystic ovary syndrome.


Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman S, Mellon PL, Lawson MA.
GLUT1-mediated Glycolysis Supports GnRH-induced Secretion of Luteinizing Hormone.
Scientific Reports, PMID: 32747664

Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Proctor EA, Kern PA, Nikolajczyk BS.
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation.
Cell Metabolism, PMID: 32402267
Featured in Cell Metabolism, Best of 2020

Nicholas DA, Salto LM, Lavelle K, Wilson J, Beeson WL, Firek A, Langridge WHR, Cordero-MacIntyre Z, De Leon M.
En Balance: The Contribution of Physical Activity to the Efficacy of Spanish Diabetes Education of Hispanic Americans with Type 2 Diabetes.
J Diabetes Res. PMID: 32377521



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