![](https://nicholaslab.bio.uci.edu/wp-content/uploads/2023/03/047-cells-1.png)
Immunometabolism
Different immune cell subtypes have specific metabolic programs that allow them to carry-out their function. The Nicholas lab has found that defects in lipid metabolism drive Th17 inflammation in type 2 diabetes. An objective of the Nicholas lab is to uncover mechanism of Th17 inflammation by investigating how manipulating T cell lipid metabolism impacts Th17 differentiation and function.