- Ortiz de Ora L, Wiles ET, Zünd M, Bañuelos MS, Haro-Ramirez N, Suder DS, Ujagar N, Ayala-Angulo J, Trinh C, Knitter C, Gonen S, Nicholas DA, Wiles TJ. Phollow reveals in situ phage transmission dynamics in the zebrafish gut microbiome at single-virion resolution. Nat Microbiol. 2025 May;10(5):1067-1083. doi: 10.1038/s41564-025-01981-1. Epub 2025 Apr 18. PubMed PMID: 40251446; PubMed Central PMCID: PMC12055606.
- Song WS, Shen X, Du K, Ramirez CB, Park SH, Cao Y, Le J, Bae H, Kim J, Chun Y, Khong NJ, Kim M, Jung S, Choi W, Lopez ML, Said Z, Song Z, Lee SG, Nicholas D, Sasaki Y, Milbrandt J, Imagawa DK, Skowronska-Krawczyk D, Chen D, Lee G, Jang C, Yang Q. Nicotinic acid riboside maintains NAD(+) homeostasis and ameliorates aging-associated NAD(+) decline. Cell Metab. 2025 Jul 1;37(7):1499-1514.e4. doi: 10.1016/j.cmet.2025.04.007. Epub 2025 May 1. PubMed PMID: 40315855; PubMed Central PMCID: PMC12328062.
- Bae H, Jung S, Le J, Tamburini I, Kim J, Wang E, Song WS, Choi W, Jang KH, Kang T, Lopez ML, Ramirez C, Mohanty I, Kelly ME, Kim J, Kim R, Park SH, Baek J, Mendez B, Petrus P, de Aguiar Vallim TQ, Nicholas DA, Smith Q, Lee G, Seldin M, Jang C. Cross-organ metabolite production and consumption in healthy and atherogenic conditions. Cell. 2025 Aug 7;188(16):4441-4455.e16. doi: 10.1016/j.cell.2025.05.001. Epub 2025 May 27. PubMed PMID: 40436017; PubMed Central PMCID: PMC12335369.
- Pacheco-Sanchez G, Herrera R, Pisarska MD, Azziz R, Nicholas DA, Chan JL. Multi-Racial Cytokine Profiling Reveals Immune Dysregulation not Chronic Inflammation in Polycystic Ovary Syndrome. J Clin Endocrinol Metab. 2025 Sep 22;. doi: 10.1210/clinem/dgaf524. [Epub ahead of print] PubMed PMID: 40976583.
- Sanchez GP, Lopez M, Velez LM, Tamburini I, Ujagar N, Angulo JA, De Robles G, Choi H, Arriola J, Kapadia R, Zonderman AB, Evans MK, Jang C, Seldin MM, Nicholas DA. Comparative Analysis of White and African American Groups Reveals Unique Lipid and Inflammatory Features of Diabetes. J Racial Ethn Health Disparities. 2025 Sep 26;. doi: 10.1007/s40615-025-02642-z. [Epub ahead of print] PubMed PMID: 41006893.
Research Articles
- Garcia C, Velez LM, Ujagar N, Del Mundo Z, Nguyen T, Fox C, Mark A, Fisch KM, Lawson MA, Duleba AJ, Seldin MM. and Nicholas DA. Lipopolysaccharide-induced Chronic Inflammation Increases Female Serum Gonadotropins and Shifts the Pituitary Transcriptomic Landscape. Front. Endocrinology 2024
- Zhou M, Tamburini I, Van C, Molendijk J, Nguyen CM, Chang IY, Johnson C, Velez LM, Cheon Y, Yeo R, Bae H, Le J, Larson N, Pulido R, Nascimento-Filho CHV, Jang C, Marazzi I, Justice J, Pannunzio N, Hevener AL, Sparks L, Kershaw E, Nicholas D, Parker BL, Masri S, Seldin MM. Leveraging inter-individual transcriptional correlation structure to infer discrete signaling mechanisms across metabolic tissues. Elife. 2024 Jan 15;12. doi: 10.7554/eLife.88863. PubMed PMID: 38224289.
- Ikrame Naciri, Minzhi Liang, Ying Yang, Heather Karner, Benjamin Lin, Maria De Lourdes Andrade Ludena, Eric Hanse, Alfredo Lebron, Olga V Razorenova, Dequina Nicholas, Mei Kong, Sha Sun. Loss of XIST lncRNA unlocks stemness and cellular plasticity in ovarian cancer. PNAS. In press 2024
- Olivia Molinar-Inglis, Kiara Wiggins, Anjali Varma, Zena Del Mundo, Jose M. Adame, Alyssa Cozzo, Oscar Muñoz, Uyen-Vy Le, Davina Trinh, Alexis C. Garcia, Metztli Cisneros-Aguirre, Monica L. Gonzalez Ramirez, Jeremiah Keyes, Jin Zhang, Mark A. Lawson, JoAnn Trejo and Dequina A. Nicholas. Insulin induces membrane surface localization of GLUT1 to increase glycolysis in murine gonadotropes. Molecular and Cellular Endocrinology. 2024 October. In press
- Leveraging genetic correlation structure to target discrete signaling mechanisms across metabolic tissues. bioRxiv. 2023 May 12;. doi: 10.1101/2023.05.10.540142. PubMed PMID: 37214953; PubMed Central PMCID: PMC10197628.
- Cell-Intrinsic CD38 Expression Sustains Exhausted CD8(+) T Cells by Regulating Their Survival and Metabolism during Chronic Viral Infection. J Virol. 2023 Apr 27;97(4):e0022523. doi: 10.1128/jvi.00225-23. Epub 2023 Apr 11. PubMed PMID: 37039663; PubMed Central PMCID: PMC10134879.
- aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis. Proc Natl Acad Sci U S A. 2021 Dec 7;118(49). doi: 10.1073/pnas.2106623118. PubMed PMID: 34873055; PubMed Central PMCID: PMC8670512.
- Nicholas DA, Knight VS, Tonsfeldt KJ, Terasaka T, Molinar-Inglis O, Stephens SBZ, Trejo J, Kauffman S, Mellon PL, Lawson MA.
GLUT1-mediated Glycolysis Supports GnRH-induced Secretion of Luteinizing Hormone.
Scientific Reports, PMID: 32747664 - Bharath LP, Agrawal M, McCambridge G, Nicholas DA, Hasturk H, Liu J, Jiang K, Guo Z, Deeney J, Apovian CM, Snyder-Cappione J, Hawk GS, Fleeman RM, Pihl RMF, Thompson K, Belkina AC, Proctor EA, Kern PA, Nikolajczyk BS.
Metformin Enhances Autophagy and Normalizes Mitochondrial Function to Alleviate Aging-Associated Inflammation.
Cell Metabolism, PMID: 32402267
Featured in Cell Metabolism, Best of 2020 - Nicholas DA, Salto LM, Lavelle K, Wilson J, Beeson WL, Firek A, Langridge WHR, Cordero-MacIntyre Z, De Leon M.
En Balance: The Contribution of Physical Activity to the Efficacy of Spanish Diabetes Education of Hispanic Americans with Type 2 Diabetes.
J Diabetes Res. PMID: 32377521
- Nicholas DA*, Proctor E*, Jones A, Agrawal M*, Belkina A, Panneerseelan-Bharath L, Raval F, Ip B, Zhu M, Cacicedo J, Persky L, Sainz-Rueda N, Habib C, Corkey B, Apovian CM, Kern P, Lauffenburger D, Nikolajczyk BS.
Fatty Acid Metabolites Combine with Reduced β oxidation to activate Th17 Inflammation in Human Type 2 Diabetes.
Cell Metabolism. PMID: 31378464.
Featured in Nature Reviews Endocrinology. Morris A. Glucose isn’t always to blame. 2019 Aug 15 ·Featured in Science Daily. University of Kentucky. “What drives inflammation in type 2 diabetes? Not glucose, says new research.” 2019 Aug 21 - Kim T, Li D, Terasaka T, Nicholas DA, Knight VS, Yang J, Lawson MA.
SRXN1 is Necessary for Resolution of GnRH-induced Oxidative Stress and Induction of Gonadotropin Gene Expression.
Endocrinology. PMID: 31504396 - Terasaka T, Kim T, Dave H, Gangapurkar B, Nicholas DA, Muñoz O, Terasaka E, Li D, Lawson MA.
The RNA-binding Protein ELAVL1 Regulates GnRH Receptor Expression and the Response to GnRH.
Endocrinology. PMID: 31188427 ·Featured in Endocrinology. MacNicol, A. ELAVL1 Elevates Insights: The Ups and Downs of Regulated mRNA Translation in the Control of Gonadotropin Release. 2019 Oct
- Nicholas DA, Zhang K, Hung C, Glasgow S, Aruni AW, Unternaehrer J, Payne KJ, Langridge WHR, De Leon M.
Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1β.
PLoS One. PMID: 28463985 - Nicholas D*, Proctor EA*, Raval FM, Ip BC, Habib C, Ritou E, Grammatopoulos TN, Steenkamp D, Dooms H, Apovian CM, Lauffenburger DA, Nikolajczyk BS.
Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis.
PLoS One. PMID: 28178278
- Kim NS, Mbongue JC, Nicholas DA, Esebanmen GE, Unternaehrer JJ, Firek AF, Langridge WH.
Chimeric Vaccine Stimulation of Human Dendritic Cell Indoleamine 2, 3-Dioxygenase Occurs via the Non-Canonical NF-κB Pathway.
PLoS One. PMID: 26881431
- Nicholas DA, Salto LM, Boston AM, Kim NS, Larios M, Beeson WL, Firek AF, Casiano CA, Langridge WH, Cordero-MacIntyre Z, De Leon M.
Identification of Anti-Long Chain Saturated Fatty Acid IgG Antibodies in Serum of Patients with Type 2 Diabetes.
Mediators Inflamm. PMID: 26633920 - Mbongue JC, Nicholas DA, Zhang K, Kim NS, Hamilton BN, Larios M, Zhang G, Umezawa K, Firek AF, Langridge WH.
Induction of indoleamine 2, 3-dioxygenase in human dendritic cells by a cholera toxin B subunit-proinsulin vaccine.
PLoS One. PMID: 25714914 - Nicholas D, Tang H, Zhang Q, Rudra J, Xu F, Langridge W, Zhang K.
Quantitative proteomics reveals a role for epigenetic reprogramming during human monocyte differentiation.
Mol Cell Proteomics. PMID: 25316709
- Odumosu O, Nicholas D, Payne K, Langridge W. Cholera toxin B subunit linked to glutamic acid decarboxylase suppresses dendritic cell maturation and function. Vaccine. 2011 Oct 26;29(46):8451-8. PMID: 21807047
Reviews/Chapters/Commentary
- Chen XW, Don AS, Fedorova M, Harayama T, Krahmer N, Nagata S, Narayan P, Nicholas D, Nowinski SM, Saheki Y, Semenkovich CF, Zhao X, Zou Y. Time for lipid cell biology. Nat Cell Biol. 2025 Feb;27(2):169-174. doi: 10.1038/s41556-025-01609-w. PubMed PMID: 39910286.
- Frascoli M, Nicholas D, Weinstock A, Hsu CL, Dongre A, Osterhout JA, Globig AM, Ramanan D, Therrien M, McCubbrey A. Women in STEM becoming independent: Asking for help creates opportunities for connections and kindness. J Exp Med. 2025 Oct 6;222(10). doi: 10.1084/jem.20251668. Epub 2025 Sep 17. PubMed PMID: 40960481.
- Nicholas DA, Mbongue JC, Garcia-Perez D, Sorensen D, Bennit HF, De Leon M, Langridge WH. Exploring the Interplay between Fatty Acids, Inflammation, and Type 2 Diabetes. Immuno. 2024 March; 4(1):91-107. doi: 10.3390/immuno4010006.
- The transition phase: preparing to launch a laboratory. Trends Biochem Sci. 2022 Oct;47(10):814-818. doi: 10.1016/j.tibs.2022.05.002. Epub 2022 May 26. PubMed PMID: 35644775; PubMed Central PMCID: PMC9677455.
- Building a laboratory and networks during the COVID-19 pandemic. Trends Biochem Sci. 2022 Sep;47(9):725-727. doi: 10.1016/j.tibs.2022.04.012. Epub 2022 May 20. PubMed PMID: 35606213; PubMed Central PMCID: PMC9121306.
- Nicholas DA, Andrieu G, Strissel KJ, Nikolajczyk BS, Denis GV.
BET bromodomain proteins and epigenetic regulation of inflammation: implications for Type 2 Diabetes and breast cancer.
Cell Mol Life Sci. PMID: 27491296
- Strissel KJ, Nicholas DA, Castagne-Charlotin M, Ko N, Denis GV.
Barriers to Obtaining Sera and Tissue Specimens of African-American Women for the Advancement of Cancer Research.
Clin Med Insights Womens Health. PMID: 27441007 - Nicholas DA, Nikolajczyk BS.
B cells shed light on diminished vaccine responses in obesity.
Obesity. PMID: 26847721.
- Mbongue JC, Nicholas DA, Torrez TW, Kim NS, Firek AF, Langridge WH.
The Role of Indoleamine 2, 3-Dioxygenase in Immune Suppression and Autoimmunity.
Vaccines. PMID: 26378585
- Mbongue J, Nicholas D, Firek A, Langridge W.
The role of dendritic cells in tissue-specific autoimmunity.
J Immunol Res. PMID: 24877157
- Nicholas D, Odumosu O, Langridge WH.
Autoantigen based vaccines for type 1 diabetes.
Discov Med. PMID: 21524383
- Odumosu O, Nicholas D, Yano H, Langridge W.
AB toxins: a paradigm switch from deadly to desirable.
Toxins. PMID: 22069653